In recent years, handheld Raman spectrometers have achieved important applications in the fields of food safety testing, rapid drug testing, and monitoring of environmental trace pollution based on their unique Raman scattering effect.

1.  Raman scattering effect

When a laser beam is irradiated onto the surface of a substance, about 0.1% of the photons collide inelastically with the molecules, resulting in a shift in the frequency of the scattered light. This phenomenon is called Raman scattering, and its displacement (Raman peaks) and intensity changes reflect molecular vibration, rotation and other information, and can be regarded as a “molecular fingerprint” of the composition and structure of matter.

 2.  Handheld Raman spectrometer

 Handheld Raman spectrometer with its light weight, compact shape, suitable for use as a handheld on-site inspection tools, especially for some special working environment of outdoor inspection. It generally adopts 785nm or 1064nm narrow linewidth lasers, whose power can be adjusted in the range of to ensure the intensity of the Raman signal of the measured samples, but also to ensure the safety of the operator.

 Relying on the built-in Principal Component Analysis (PCA) and Partial Least Squares (PLS) advanced algorithms, we are not only able to separate and quantitatively analyze the qualitative and quantitative components of complex mixtures, but also to quantitatively analyze the complex components with better resolution and accuracy.

 The handheld Raman spectrometer can quickly identify the substance of the measured sample within 30 seconds and does not require complex pre-treatment of the sample.

3. Application Scenarios:

 -The detection of many indexes of food, such as the pesticide residue, the common additives of food such as melamine, etc. should be done to achieve the safety standard….

 -The identification of antibody drugs such as anti-PD-1, the variation of the size of different molecules and its charge isomerization, etc., which better solves the difficulties in the identification of antibody drugs in the clinic, and is of great significance to the research and development of antibody drugs and their clinical application in the future.

 -The continuous improvement of the means of industrial safety, we will be able to the vulnerable chemicals such as acetone and a variety of explosives invisible killers can be quickly identified.

4. Handheld Raman spectrometer light source: narrow linewidth diode laser

By its handheld characteristics, the laser light source used for Raman spectrometer is a compact structure and high performance and narrow linewidth diode laser. As a global leading supplier of light sources for Raman spectrometers, RealLight provides users with a wide range of small-sized, wavelength stabilized diode lasers in various packages, covering a wide range of wavelengths, including 532nm, 638nm, 785nm, 830nm and 1064nm.

narrow linewidth diode laser

narrow linewidth diode laser

With its fast detection speed, portable experience and intelligent analyzing function, the handheld Raman spectrometer has achieved irreplaceable advantages and status in the fields of food safety detection, rapid identification of drugs and industrial safety monitoring. With the enhancement of nanogold and the continuous integration of AI algorithms, the limit of detection will be further broken, and will even be extended to a wide range of applications in emerging biomedical fields such as early diagnosis of cancer and new generation research of materials.

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